西北农林科技大学理学院导师介绍:王进义
基本信息
王进义, 男, 汉族, 甘肃甘谷人, 1969年12月出生, 博士, 教授, 博士生导师。陕西省优秀留学回国人员, 教育部新世纪优秀人才支持计划获得者。
教育背景
2004年―2006年: 博士后, 美国加州大学洛杉矶分校, David Geffen医学院
2002年―2004年: 博士后, 中国科学院上海有机化学研究所
1997年―2002年: 博士, 兰州大学 (硕博连读)
1989年―1993年: 学士, 北京化工大学
研究方向
(1) 功能生物纳米材料的合成及其在生命分析中的应用; (2) 微流控芯片生物传感; (3) 微流控芯片细胞生物技术。
论文发表
[1] Q. Tu, L. Li, Y. Zhang, J. C. Wang, R. Liu, M. Li, W. Liu, X. Wang, L. Ren, J. Wang.* The effect of acetylcholine–like biomimetic polymers on neuronal growth. Biomaterials 2011, 32(12):3253–3264.
[2] P. Sun, Y. Liu, J. Sha, N. Song, Q. Tu, P. Chen, J. Wang.* High–throughput microfluidic system for long–term bacterial colony monitoring and antibiotic testing in zero–flow environments. Biosens. Bioelectron. 2011, 26(5):1993–1999.
[3] J. F. Wang, W. Liu, Qin Tu, J. C. Wang, N. Song, Y. Zhang, N. Nie, J. Wang.* Folate–decorated hybrid polymeric nanoparticles for chemically and physically combined paclitaxel loading and targeted delivery. Biomacromolecules 2011, 12(1):228–234.
[4] X. Wang, L. Ren, Q. Tu, J. C. Wang, Y. Zhang, J. Wang.* Magnetic protein microbead–aided indirect fluoroimmunoassay for the determination of canine virus specific antibodies. Biosens. Bioelectron. 2011, 26(7):3353–3360.
[5] H. Wu, W. Liu, Q. Tu, N. Song, L. Li, J. C. Wang, J. Wang.* Culture and chemical–induced fusion of tobacco mesophyll protoplasts in a microfluidic device. Microfluid. Nanofluid. 2011, 10(4):867-876.
[6] X. Huang, L. Li, Q. Tu, W. Liu, J. C. Wang, J. Wang.* On–chip cell migration assay for quantifying the effect of alcohol on breast cancer cells. Microfluid. Nanofluid. 2011, 10(6):1333–1341.
[7] B. Shang, J. Sha, Y. Liu, Q. Tu, M. Li, J. Wang.* Synthesis of a new chitosan derivative and assay of Escherichia coli adsorption. J. Pharm. Anal. 2011, 1(1):39–45.
[8] Z. Zhang, J. C. Wang, Q. Tu, N. Nie, J. Sha, R. Liu, Y. Zhang, J. Wang.* Surface modification of PDMS by surface-initiated atom transfer radical polymerization of water-soluble dendronized PEG methacrylate. Colloids Surf., B 2011, In press.
[9] N. Song, W. Liu, Q. Tu, R. Liu, Y. Zhang, J. Wang.* Preparation and in vitro properties of redox-responsive polymeric nanoparticles for paclitaxel delivery. Colloids Surf., B 2011, In press.
[10] J. Sha, Y. Wang, J. C. Wang, L Ren, Q. Tu, W. Liu, X. Wang, A. Liu, L. Wang, J. Wang.* Capillary-composited microfluidic device for heat shock transformation of Escherichia coli. J. Biosci. Bioeng. 2011, In press.
[11] J. Sha, Y. Wang, J. C. Wang, W. Liu, Q. Tu, A. Liu, L. Wang, J. Wang.* Heat-shock transformation of Escherichia coli in nanolitre droplets formed in a capillary-composited microfluidic device. Analy. Methods 2011, In press
[12] Y. Liu, J. C. Wang, L. Ren, Q. Tu, W. Liu, X. Wang, R. Liu, Y. Zhang, J. Wang.* Microfluidics-based assay on the effects of microenvironmental geometry and aqueous flow on bacterial adhesion behaviors. J. Pharm. Anal. 2011, In press.
[13] J. Wang, W. Liu, L. Li, Q. Tu, J. C. Wang, L. Ren, X. Wang, A. Liu. Microfluidics-based cell manipulation and analysis (Book Chapter). Biomimetic ISBN 978-953-307-271-5.
[14] L. Yang, L. Li, Q. Tu, L. Ren, Y. Zhang, X. Wang, Z. Zhang, W. Liu, X. Liang, J. Wang.* Photocatalyzed surface modification of poly(dimethylsiloxane) with polysaccharides and assay of their protein adsorption and cytocompatibility. Anal. Chem. 2010, 82(15):6430–6439.
[15] W. Liu, L. Li, X. M. Wang, L. Ren, X. Wang, J. C. Wang, Q. Tu, X. Huang, J. Wang.* An integrated microfluidic system for studying cell–microenvironmental interactions versatilely and dynamically. Lab Chip 2010, 10(13):1717–1724.
[16] W. Liu, P. Sun, L. Yang, J. F. Wang, L. Li, J. Wang.* Assay of glioma cell responses to ananticancer drug in a cell–based microfluidic device. Microfluid. Nanofluid. 2010, 9(4–5):717–725.
[17] L. Li, W. Liu, J. C. Wang, Q. Tu, R. Liu, J. Wang.* Lectin–aided separation of circulating tumor cells and assay of their response to an anticancer drug in an integrated microfluidics. Electrophoresis 2010, 31(18):3159–3166.
[18] L. Ren, X. Wang, H. Wu, B. Shang, J. Wang.* Conjugation of nattokinase and lumbrukinase with magnetic nanoparticles for the assay of their thrombolytic activities. J. Mol. Catal. B: Enzym. 2010, 62(2):190–196.
[19] J. Wang,* X. Wang, L. Ren, Q. Wang, L. Li, W. Liu, Z. Wan, L. Yang, P. Sun, L. L. Ren, M. Li, H. Wu, J. F. Wang, L. Zhang.Conjugation of biomolecules with magnetic protein microspheres for the assay of early biomarkers associated with acute myocardial infarction. Anal. Chem. 2009, 81(15):6210–6217.
[20] J. Wang,* L. Ren, L. Li, W. Liu, J. Zhou, W. Yu, D. Tong, S. Chen. Microfluidics: A new cosset for neurobiology. Lab Chip 2009, 9(5):644–652.
[21] J. Wang,* L. Ren, X. Wang, Q. Wang, Z. Wan, L. Li, W. Liu, X. M. Wang, M. Li, D. Tong, A. Liu, B. Shang. Superparamagnetic microsphere–assisted fluoroimmunoassay for rapid assessment of acute myocardial infarction. Biosens. Bioelectron. 2009, 24(10):3097–3102.
[22] J. Wang,* Z. Wan, W. Liu, L. Li, L. Ren, X. Wang, P. Sun, L.i Ren, H. Zhao, Q. Tu, Z. Zhang, N. Song, L. Zhang. Atomic force microscope study of tumor cell membranes following treatment with anticancer drugs. Biosens. Bioelectron. 2009, 25(4):721–727.
[23] J. Wang,* Q. Wang, L. Ren, X. Wang, Z. Wan, W. Liu, L. Li, M. Li, D. Tong, J. Xu. Carboxylated magnetic microbead–assisted fluoroimmunoassay for early biomarkers of acute myocardial infarction. Colloids Surf., B 2009, 72(1):112–120.
[24] Z. Sun, C. Hu*, J. Wang.* A new sesquiterpene from caragana intermediia and its anti–pyricularia oryzae P–2b activity. Chin. J. Chem. 2008, 26(5):831–834.
[25] D. Tong,* J. Wang,* P. Mu, Q. Dong, B. Zhao, W. Liu, J. Zhao, L. Li, T. Zhou. Analysis of several serum enzymes and blood urea nitrogen of swainsonine–HSA immunized goats. Anim. Feed Sci. Tech. 2008, 142(1–2):74–88.
[26] 王进义,* 王雪琴, 刘文明, 李立, 童德文, 杨兵力, J. Zhou, W. Yu. 微流控芯片技术及其在血液分析中的研究进展, 西北农林科技大学学报(自然科学版) 2008, 36(9):203–211.
[27] Z. Sun, C. Hu, J. Wang.* A new sesquiterpene from Caragana intermediia. Chin. Chem. Lett. 2007, 18(11):1379–1382.
[28] D. Tong,* P. Mu, Q. Dong, B. Zhao, W. Liu, J. Zhao, L. Li, T. Zhou, J. Wang.* G. Sui.* Immunological evaluation of SW–HSA conjugate on goats. Colloids Surf., B 2007, 58(1):61–67.
[29] D. Tong, H. Yang, J. Wang.* Recent advances in the synthesis of artificial antigen and its application in the detection of pesticide residue. Am. J. Agric. Biol. Sci. 2007, 2(2):88–93.
[30] J. Wang, G. Sui, V. P. Mocharla, R. J. Lin, M. E. Phelps, H. C. Kolb, H.–R. Tseng. Integrated microfluidics for parallel screening of an in situ click chemistry library. Angew. Chem. Int. Ed. 2006, 45(32):5276–5281.
[31] G. Sui,† J. Wang,† C. C. Lee, S. P. Lee, J. V. Leyton, A. M. Wu, H.–R. Tseng. Solution–phase surface modification in intact poly(dimethylsiloxane) microfluidic channels. Anal. Chem. 2006, 78(15):5543–5551 († contributed equally).
[32] S. P. Li, X. J. Zhao, J. Wang. Synergy of astragalus polysaccharides and probiotics (Lactobacillus and Bacillus cereus) on immunity and intestinal microbiota in chicks. Poultry Sci. 2009, 88(3):519–525.
[33] G. Sui, C.–C. Lee, K.–I. Kamei, H.–J. Li, J. Wang, Ju. Wang, H. R. Herschman, H.–R. Tseng. A microfluidic platform for sequential ligand labeling and cell binding analysis. Biomed. Microdevices 2007, 9(3):301–305.
[34] L. Zhang, J. Wang, W. Wang, Y.–X. Cui, D. Cheng. Two new alkaloidal glycosides from the root bark of Ailanthus altissima. J. Asian. Nat. Prod. Res. 2007, 9(3):253–259.
[35] J. Wang, Y. L. Bunimovich, G. Sui, S. Savvas, J. Wang, Y. Guo, J. R. Heath, H.–R. Tseng. Electrochemical Fabrication of Conducting Polymer Nanowires in an Integrated Microfluidic System. Chem. Commun. 2006, 29:3075–3077.
[36] G. Sui, J. Wang, Z. T. F. Yu, J. V. Leyton, A. M. Wu, H. R. Tseng. Surface modification of PDMS–surfaces for protein–passivation, cell immobilization, DNA array and immunoassay. Polymer Preprints, 2006, 47(1):290–291.
[37] D. Tong, J. Wang, P. Brain, G. Ravi. Seasonal change of loline alkaloids in endophyte –infected meadow fescue. Agric. Sci. China 2006, 5(10):101–105.
[38] D. Ma, X. Pu, J. Wang. Efficient formal synthesis of the dendrobatid alkaloid, indolizidine (-)-209B. Tetrahedron: Asymmetry 2002, 13(20): 2257-2260.
[39] J. Zhou, J. Wang, N. Tang. The mechanisms of the binding of quercetin•2H2O and LaL3•6H2O to ctDNA. Indian J. Chem.: Inorg., Phys., Theor. Anal. Chem. 2001, 40A:149-154.
[40] J. Zhou, L. Wang, J. Wang, N. Tang. Antioxidative and antitumour activities of solid quercetin metal (II) complexes. Transition Met. Chem. 2001, 26: 57-63.
[41] J. Wang, J. Zhou, D. Cheng, P. Jian, G. Zhang. Synthesis and Crysyal Structure of (+/-)-1-[(2-hydroxy-5-methylphenyl)(phenyl)methyl]-2-pyridybenzimidazole.高等学校化学学报 2000, 12: 1861-1863.
[42] J. Wang, D. Cheng. Crystal structure and electrode reaction of 2-[α- (2-aminophenylimino)benzyl]-4-cresol. 兰州大学学报(自然科学版), 2000, 36(6): 61-65 (EI 收录).
[43] J. Wang, G. Zhang, D. Cheng, F. Wu. Chemical constituents of Rosa laevigata Michx. 天然产物研究与开发, 2001, 13(1): 21-23.
[45] 周晶, 王进义, 唐宁, 槲皮素与金属Cd(II) Sc(III)配合物的合成及抗氧性研究, 兰州大学学报(自然科学版), 2001, 37 (1), 123-125.
[46] J. Zhou, J. Wang, G. Gong, L. Wang, N. Tang. Interaction between DNA and complex of quercetin with Cu(II). 兰州大学学报(自然科学版), 2000, 36(6), 131-133.
授权与申报专利
[1] H.-R. Tseng, J. Wang, G. Sui, Y. Wang, W.-Y. Lin. Integrated microfluidics for highly parallel screening of chemical reactions. International Publication Number: WO2009/009021 A1. International Publication Date: 15 January 2009.
[2] H.-R. Tseng, G. Sui, J. Wang. Method for microchannel surface modification. International Publication Number: WO2007/047644 A2. International Publication Date: 26 April 2007.
[3] 李旭东, 王进义, 周春红, 张正艮, 杨方明. 一种4-氯-3-硝基苯甲醚的制备方法. 专利号: ZL03131914.9.
[4] 王进义,刘文明,李立,宋鹏,王旭明,王雪琴,任丽,任莉莉. 一种集成微流控芯片及其用于活细胞控制与分析的应用,申请(专利)号: 200910023164.5. 申请日: 2009.07.02, 公开(公告)号: CN101597568.
[5] 林国强, 马景毅, 徐亮, 孙逊, 孙智华, 王进义. 一种合成非手性、非肽类的抗凝血酶抑制剂的方法, 申请(专利)号: 200610082286.8. 申请日: 2006.05.18, 公开(公告)号: CN1861596.
[6] 王进义, 李旭东, 林国强, 张正艮. 3-(甲酰胺)-7-(甲磺酰胺)-6-(苯氧基)-4H-1-(苯并吡喃)-4-酮的制备方法. 申请(专利)号: 03131916.5. 申请日: 2003.06.18, 公开(公告)号: CN1462748.
[7] 林国强, 王进义, 李旭东, 谈忠兴, 刘汉泉. (R)-氟比洛芬在药效活性领域的新用途. 申请(专利)号: 200310108342.7. 申请日: 2003.10.31, 公开(公告)号: CN1539412.
[8] 张正艮, 李旭东, 王进义, 王林. 一种难溶性药物片剂及其制备方法. 申请(专利)号: 03113470.X. 申请日: 2003.05.16, 公开(公告)号: CN1451373.
联系方式
联系地址: 陕西、杨凌、西北农林科技大学理学院, 邮编: 712100.
电话: 029-87082520.
电子邮件: jinyiwangpharm@gmail.com; jywang@nwsuaf.edu.cn
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