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中国计量学院生命科学学院导师介绍：周益峰

周益峰（1979~ ），男，博士、副教授、硕士生导师。

教育背景：

1998.9~2002.7，在兰州大学生物学国家基础理论研究与教学人才培养基地班学习，获理学学士学位；

2002.9~2007.6，兰州大学生命科学学院生物化学与分子生物学研究所硕博连读研究生；从事多肽与手性药物化学方面的研究工作，获理学博士学位；

工作情况：

2007.6~至今，中国计量学院生命科学学院，教师。主讲《药物化学》、《药物合成反应》、《高等有机化学》。

研究方向：

有机合成，多肽药物与手性药物化学、原料药创新路线合成开发。

主要荣誉：

中国科学院奖学金

香港求是基金会求是研究生奖学金

Tetrahedron：Asymmetry Most Cited Paper 2003-2006 Award

主要成果：

一、主持的科研项目

1．他苏洛辛中间体S异构体的消旋化技术开发及应用（2010C11031）浙江省重大科技专项 63万

2．有机催化炔对醛和酮的不对称加成反应研究（Y200702756）浙江省教育厅项目 1万

3．奥美沙坦酯开发及应用（2010-1-123）金华市科学技术研究计划项目

4．若干原料药及中间体创新合成工艺开发（03106-101034）浙江普洛医药科技有限公司 100万

5．酪胺的新工艺研究（03106-092129）浙江普洛医药科技有限公司 15万

6．拉科酰胺的合成工艺开发（03106-101095）Avilive USA 2万美元

7．Laropiprant的合成工艺开发（03106-102220）Avilive USA 2万美元

8．Telaprevir的合成工艺开发（03106-112063）Magnifica Inc USA 2.5万美元

9．Lorcaserin合成工艺开发（03106-122078）Magnifica Inc USA 3.6万美元

10．Iron Dextran的合成工艺开发（03106- ）Magnifica Inc USA 6万美元

二、参加的科研项目

1．2005.1~2007.12，国家自然科学基金（20472026）：新设计的磺酰胺配体的合成和固载及其催化的不对称炔加成反应

2．2004.1~2006.12，国家自然科学基金（20372028）：均相和非均相C2-轴光活性氨基苯酚的不对称合成与不对称催化反应

3．天然抗癌药咖啡酸苯乙醇酯绿色化学合成关键技术研发（2008C11045）浙江省重大科技专项

三、论文及专利

1．Long Qin, Lei Li, Lei Yi, Chaoshan Da, Yifeng Zhou. Direct Asymmetric N-Specific Reaction of Nitrosobenzene with Aldehydes Catalyzed by a Chiral Primary Amine-Based Organocatalyst Chirality 2011, 23, 527-533(通讯作者)

2．Weifeng Xu, Qin Chen, Ruiqi Liu, Fengbo Ren, Yifeng Zhou, Xiulian Lu.Synthesis of b-Amino Cyclone Catalyzed by Alkaline Al2O3 Asian Journal of Chemistry 2011,9, 4165-4168 (通讯作者)

3．Yifeng Zhou, Rui Wang, Zhaoqing Xu, Wenjin Yan, Lei Liu, Yongfeng Kang, Zhijian Han.Highly Enantioselective Phenylacetylene Additions to Ketones Catalyzed by (S)-BINOL-Ti Complex. Org. Lett. 2004, 23, 4147.

4．Yifeng Zhou, Rui Wang, Zhaoqing Xu, Wenjin Yan, Lei Liu, Yanfeng Gao, Chaoshan Da.Boc-L-proline as A New Chiral Ligand for Enantioselective Phenylacetylene Addition to Aromatic Aldehydes. Tetrahedron: Asymmetry 2004, 15, 589.

5．Yifeng Zhou, Yanfeng Gao, Yongfeng Kang, Zhijian Han, Wenjin Yan, Ming Ni, Rui Wang.Peptide Derivatives as New Chiral Ligands for Enantioselective Phenylacetylene Addition to Aldehydes. Chin. J. Org. Chem. 2004, 24, suppl, 162.

6．Yifeng Zhou, Zhijian Han, Li Qiu, Jinyan Liang, Fengbo Ren, Rui Wang. Asymmetric Addition of Phenylacetylene to Aromatic Ketones Catalyzed by Zinc or Titanium Complexes with Chiral Hydroxysulfonamide. Chirality 2009, 21, 473-479.

7．Ming Ni, Yifeng Zhou, Chao Chen, Jiangke Xu, Rui Wang. Enantioselective Alkynylation of Ketones Promoted by β-Sulfonamide Alcohol-titanium Complexes.Chin. J. Chem. 2007, 25, 694-697.

8．Zhijian Han, Rui Wang, Yifeng Zhou, Lei Liu. Simple Derivatives of Natural Amino Acids as Chiral Ligands in the Catalytic Asymmetric addition of Phenylacetylene to Aldehydes.Eur. J. Org. Chem. 2005, 934.

9．Yongfeng Kang, Lei Liu, Rui Wang, Yifeng Zhou, Wenjin Yan. Enantioselective Alkynylation of Aromatic Ketones Catalyzed by New Chiral Oxazolidine Ligands.Adv. Synth. Catal. 2005, 347, 243.

10．Lei Liu, Yongfeng Kang, Rui Wang, Yifeng Zhou, Chao Chen, Ming Ni, Maozhen Gong.Enantioselective Alkynylation of Aromatic Ketones Promoted by (S)-Phenylalanine-derivedβ-Amino Alcohol. Tetrahedron: Asymmetry 2004, 15, 3757.

11．Yongfeng Kang, Lei Liu, Rui Wang, Wenjin Yan, Yifeng Zhou. The Use of Bifunctional Catalyst Systems in the Asymmetric Addition of Alkynylzinc to Aldehydes.Tetrahedron: Asymmetry 2004, 15, 3155.

12．Zhijian Han, Chaoshan Da, Zhaoqing Xu, Ming Ni, Yifeng Zhou, Rui Wang.The Natural Amino Acid Derived Chiral Sulfonamide Ligands in the Catalytic Asymmetric Addition of Phenylacetylene to Aldehydes. Lett. Org. Chem. 2006, 3, 143.

13．Lei Liu, Rui Wang, Yongfeng Kang, Chao Chen, Zhaoqing Xu, Yifeng Zhou, Ming Ni,Huaqing Cai, Maozhen Gong. Highly Enantioselective Phenylacetylene Additions to Aromatic Ketones Catalyzed by Cinchona Alkaloid Aluminum Complexes.J. Org. Chem. 2005, 70, 1084.

14．Chaoshan Da, Zhijian Han, Ming Ni, Fan Yang, Daxue Liu, Yifeng Zhou, Rui Wang.A Convenient Synthesis of Piperidine-based β-Amino Alcohols from L Phe and Highly Enantioselective Addition of Diethyl Zinc to Aldehydes.Tetrahedron: Asymmetry 2003, 14, 659.

15．Wenjin Yan, Rui Wang, Zhaoqing Xu, Jiangke Xu, Li Lin, Zhiqiang Shen, Yifeng Zhou.A Novel, Practical and Green Synthesis of Ag Nanoparticles Catalyst and Its Application in Three-Component Coupling of Aldehydes, Alkyne, and Amine.J. Mol. Catal. A: Chemical 2006, 25, 81.

16．Yanfeng Gao, Xin Liu, Weixia Liu, Yuanming Qi, Xuefeng Liu, Yifeng Zhou, Rui Wang.Opioid Receptor Binding and Antinociceptive Acitivity of the Analogues of Endomorphin-2 and Morphiceptin with Phenylalanine Mimics in the Position 3 or 4.Bioorg. Med. Chem. Lett. 2006, 16, 3688.

17．手性氨基酸或其衍生物的消旋方法周益峰吴朝刚王海云等ZL200910098520

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