南京航空航天大学自动化学院导师介绍：宋晓峰

2、计算系统生物学理论与算法。

目前本课题组主要采用计算系统生物学研究手段研究人类复杂疾病的分子调控机制，诸如miRNA介导的人类疾病基因表达调控机制，相关蛋白降解异常所致疾病的分子机制，为相关疾病的诊断和治疗提供帮助等。

(1)Xiaobai Zhang, Juan Cui, Daniel Nilsson; Kapila Gunasekera; Isabel Roditi; Astrid Chanfon; Xiaofeng Song, Huinan Wang, Ying Xu and Torsten Ochsenreiter. The Trypanosoma brucei Mitocarta and its Regulation and Splicing Pattern during Development. Nucleic Acids Research. 2010,38(21):7378-7387. (SCI# 689TK, IF# 7.279)

(2)Xiaofeng Song, Lei Cheng. microDoR: Predicting miRNA-Mediated Gene Silencing, mRNA degradation or translational repression. Comput. Biol. Med.. (to appear, 2011) （SCI, IF#1.485）

(3)Xiaofeng Song, Hao Jia, et.al.Recognition of short-lived proteins based on sequence-derived features in eukaryotic cell. PLoS ONE. (to appear, 2011) （SCI, IF#4.78）

(4)Xiaofeng Song, Peipei Wang.Flexible Array Self-Organizing Map Neural Network and Its Application in Complex Pattern Recognition. Neural Computing and Application, 2011,20(1):9-16. (SCI# 712NZ, IF# 1.088)

(5)Xiao-feng Song, Wei-min Chen, Yi-Ping Phoebe Chen, Bin Jiang. Candidate Working Set Strategy based SMO Algorithm in Support Vector Machine. Inform. Process. & Manag. 2009,45(5): 584-592.（SCI# 481FP, IF# 2.106）（corresponding author）

(6)Xiao-feng Song, Yan Hao. Adaptive Evolution of Rotavirus VP7 & NSP4 Genes in Different Species. Comput. Biol. Chem. 2009, 33(4): 344-349.（SCI# 495BM, IF# 1.733）（corresponding author）

(7)Xiao-feng Song，Ping Han，Yi-Ping Phoebe Chen. Genetic variation of the hemagglutinin of avian influenza virus H9N2. J. Med. Virol. 2011,83(5):838-846.（SCI#736BL, IF# 2.572）

(8)Xiao-feng Song，Saman K Halgamuge, CHEN De-zhao, HU Shang-xu, and Bin Jiang. The Optimized Support Vector Machine with Correlative Features for Classification of Natural Spearmint Essence. Int. J. Innov. Comp. Inf. Con., 2010, 6(3): 1089-1099, (SCI# 571PW, IF#2.735) （corresponding author）

(9)Xiaofeng Song, Chen,Weimin, Jiang,bin. Sample reducing method in Support Vector Machine based on K-closed Sub-clusters, Int. J. Innov. Comp. Inf. Con.，2008,4(7):1751-1760 (SCI#326XS, IF#2.735) （corresponding author）

(10)Xiaobai Zhang. Xiaofeng Song, Huinan Wang. Sequential Local Least Squares Imputation Estimating Missing Value of Microarray Data. Comput. Biol. Med., 2008,38(10): 1112-1120. (SCI#368QN, IF#1.485) （corresponding author）

(11)Xiaobai Zhang. Xiaofeng Song, Huinan Wang。Characteristic comparison between two types of miRNA precursors in metazoan species。BioSystems,2010,100(2):144-149. (SCI# 599MX, IF#1.653）（corresponding author）

(12)Zhang huanping, Xiaofeng Song, Huinan Wang, Xiaobai Zhang. MIClique: An Algorithm to Identify Differentially Coexpressed Disease Gene Subset from Microarray Data. J. Biomed. Biotechnol.. 2009, doi:10.1155/2009/642524（SCI#560FT, IF#2.647）（corresponding author）

(13) Minghao Wang, Xiaofeng Song，Ping Han, Wei Li, Bin Jiang. New syntax to describe local continuous structure-sequence information for recognizing new pre-miRNAs. Journal of Theoretical Biology. 2010,264(2):578-584.（SCI# 588GG, IF#2.738）（corresponding author）

(14) Hui Yi, Xiaofeng Song, and Bin Jiang. Structure Selection of Support Vector Machine based on Decision Directed Acyclic Graph based on Misclassification Loss Minimization. Int. J. Innov. Comput. I..2011, 7(9) (accepted) （co-corresponding author）

主持江苏省自然科学基金（BK2010500）；

主持校级教改项目三项；

参与国家级或部级科研项目十多项；

目前指导硕士研究生9名，协助指导博士研究生2名。

已毕业研究生12名，分别进入德国博世、西门子、华为、中兴等世界500强公司企业从事软件工作，本课题组毕业的博士生进入同济大学、南京林业大学等著名高校工作。

本课题组已经与美国、澳大利亚、香港等地高校建立密切的合作关系，在校期间，优秀的研究生将有机会进入美国，香港等高校进行合作研究。

课题组主页：http://bioinfo.nuaa.edu.cn