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中国药科大学药学院导师介绍：钱海

钱海博士，副教授

2001年毕业于山东大学药学院药学专业，2007 获中国药科大学药物化学专业博士学位。现任职药学院新药研究中心，主要从事药物化学教学与新药的设计合成及构效关系研究。2010年获第13届中国药学会-施维雅青年药物化学奖。

研究方向：

心脑血管药物及多肽药物的设计合成及生物活性研究。

科研项目：

现主持教育部科学技术研究重点项目和教育部博士点研究项目各一项，参与国家“十一五”新药创制重大专项临床前和候选药物各一项，承担企业横向课题一项。

近期代表论著：

现已发表论文14篇（SCI收录 13篇），申请专利 8 项（授权4项）。

1. Xiaoyun Zhu, Dandan Huang, Xiaobu Lan, Chunlei Tang, Yan Zhu, Jing Han, Wenlong Huang*, Hai Qian*. The first pharmacophore model for potent G protein-coupled receptor 119 agonist. European Journal of Medicinal Chemistry， 2011,46 (7), 2901–2907.

2. Zhi-hong Zou, Xiao-bu Lan, Hai Qian*, Wen-long Huang*, Yun-man Li. Synthesis and evaluation of furoxan-based nitric oxide-releasing derivatives of tetrahydroisoquinoline as anticancer and multidrug resistance reversal agents. Bioorganic & Medicinal Chemistry Letters，2011 , 21 (19), 5934–5938.

3. Bin Wang, Jing Li, Wen Long Huang*, Hui Bin Zhang, Hai Qian*, Yong Tang Zheng. Synthesis and biological evaluation of andrographolide derivatives as potent anti-HIV agents . Chinese Chemical Letters，2011, 22 (7),781–784.

4. Liang Ge, jingjie Wang, Xiaoyan Zhang, Huibin Zhang, Hai Qian*, Wenlong Huang and Jinpei Zhou*. Synthesis and Biological Evaluation of Nitric Oxide-releasing Derivatives of Capsaicin as Analgesia Drugs. Letters in Drug Design & Discovery, 2011, 8(1), 76-81.

5. Jinpei Zhou, Shuaijian Ni, Huibin Zhang, Hai Qian*, Yushi Chi, Wenlong Huang, Lu Yu, Xiaowen Hu and Wei Chen. Synthesis and Bioactivity Evaluation of Dipeptidyl Peptidase IV Resistant Glucagon-like Peptide-1 Analogues. Protein & Peptide Letters, 2010, 17 (10), 1290-1295.

6. Hai Qian, Zhixian Fu, Wenlong Huang, Huibin Zhang, Jinpei Zhou, Liang Ge*, Rui Lin, Haiyan Lin and Xiaowen Hu. Synthesis and Preliminary Biological Evaluation of Capsaicin Derivatives as Potential Analgesic Drugs. Medicinal Chemistry, 2010, 6(4), 205-210.

7. Hai Qian, Wei Chen, Xiaoyan Zhang, Huibin Zhang, Jinpei Zhou*, Wenlong Huang*, Jing Jin and Dongyan Dai. Synthesis and Biological Evaluation of Dihydroisoquinoline-2(1H)-Carbothioamide Derivatives as TRPV1 Antagonists. Letters in Drug Design & Discovery, 2010, 7(4), 235-237.

8. Hai Qian, Wei Chen, Jin Pei Zhou*, Wen Long Huang*, Hui Bin Zhang, Jing Jin. Total synthesis of endothelin 1 by microwave-assisted solid phase method. Chinese Chemical Letters. 2010, 21(4), 388-390.

9. Hai Qian, Zhixian Fu, Huibin Zhang, Jinpei Zhou*, Wenlong Huang*, Jing Jin, Wei Chen and Dongyan Dai. Synthesis and Biological Evaluation of Capsaicin Derivatives as Analgesia Drugs. Letters in Drug Design & Discovery, 2010, 7(2), 122-127.

10. Jian Feng Ji , Hui Bin Zhang, Wen Long Huang*, Hai Qian*, Jin Pei Zhou. A convenient synthesis of ezetimibe analogs as cholesterol absorption inhibitors. Chinese Chemical Letters, 2010, 21 (1), 67-69.

11. Jinpei Zhou, Xiaowen Hu, Huibin Zhang, Hai Qian*, Wenlong Huang, Fan Qi and Yanchun Zhang. Synthesis and Biological Evaluation of 5,6-Dihydro- benzo[c] acridin-7-ol Derivatives as Anti-Alzheimer’s Disease Drugs. Letters in Drug Design & Discovery, 2009, 6(8), 623-628.

12. Jinpei Zhou, Huibin Zhang, Hai Qian*, Liang Lin, Wenlong Huang* and Shuaijian Ni. Synthesis and Biological Evaluation of Aromatase Inhibitors. Letters in Drug Design & Discovery, 2009, 6(3), 181-185.

13. 钱海,黄文龙,饶光玲,葛亮,吴晓明.香蕉皮中3-甲基-7, 8-二羟基异色满酮-4的含量测定.中国药科大学学报. 2009, 40(6): 524-526.

14. Qian, Hai; Huang, WenLong; Wu, XiaoMing; Zhang, HuiBing; Zhou, JinPei; Ye, WenCai, A new isochroman- 4-one derivative from the peel of Musa sapientum L. and its total synthesis. Chinese Chemical Letters, 2007, 18, (10), 1227-1230.

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